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Celebrex recently became the only drug federally approved for reducing the number of polyps in patients with familial adenomatous polyposis. Certain medical tests and provide unusual results. Celebrex recently became the only drug federally approved for reducing the number of polyps in patients with polyposis. Celebrex can increase the risk of developing bleeding stomach ulcers or a sudden kidney failure. Celecoxib should only be used in pregnant women when the benefits outweigh the potential risk to the fetus.